The Dow Jones Industrial Average rose 122.73 points, or 0.46 percent, to 26,773.94, the S&P 500 lost 1.16 points, or 0.04 percent, to 2,923.43 and the Nasdaq Composite dropped 37.76 points, or 0.47 percent, to 7,999.55.
The Dow hit a record closing high on Tuesday, but another drop in Facebook shares weighed on both the S&P 500 and Nasdaq, driving both to finish in the red.
The NYSE FANG+TM index , an equal-weighted index of five core FANG stocks, was down 4.2 percent for September.
The smallcap Russell 2000 index was off 1.01 percent. Smaller names, which had been viewed as being more insulated to trade pressures, are losing their lustre following Sunday's late-night North American trade agreement. The index is now down nearly 5 percent from its August 31 high.
The S&P 500 posted 20 new 52-week highs and 11 new lows; the Nasdaq Composite recorded 35 new highs and 124 new lows.Volume on US exchanges was 7.19 billion shares, compared to the 6.93 billion average for the full session over the last 20 trading days.
